MT: Delivery Strategies; antisense oligonucleotide; central nervous system; delivery; distribution; gymnosis; immunoelectron microscopy; lipid nanoparticles; trafficking

Lipid nanoparticle delivery limits antisense oligonucleotide activity and cellular distribution in the brain after intracerebroventricular injection
Antisense oligonucleotide (ASO) therapeutics are being investigated for a broad range of neurological diseases. While ASOs have been …