Ben Laufer
Ben Laufer

Principal Scientist II

Genentech

About

Ben Laufer is a computational biologist who researches gene expression and neuroscience. He is part of the Neuroinformatics Group in the Department of Computational Biology & Medicine at Genentech.

Interests
  • Bioinformatics
  • Gene Regulation
  • Neuroscience
Education

  • Postdoctoral Fellowship

    University of California Davis, USA

  • PhD in Cellular & Molecular Biology

    Western University, Canada

  • BSc (Hons) in Genetics

    Western University, Canada

Recent Publications
Soumitra Ghosh, Yuchen Fan, Benjamin I. Laufer, William Stephenson, Nanzhi Zang, Jessica Lawrence, Han H. Lin, Sanjana Sen, Stephen E. Miller, Sarah Chu, Jose Imperio, Eric Lubeck, Chun-Wan Yen, William J. Meilandt, Stephanie Monson, Baris Bingol, Brad A. Friedman, Whitney Shatz-Binder (2025). Multiplex screening of transferrin receptor-targeted lipid nanoparticles for systemic brain delivery using DNA barcodes. Cell Biomaterials.
DOI
Baixue Xiao, Soojin Kim, Benjamin I. Laufer, Anthony Antonelli, Milena Hornburg, Divya Murali, Yimin Gu, Pierce Jessen, Diamanda Rigas, Rebecca Leylek, Keiko Hokeness, Emily Freund, Eric Torres, Gaia Ruggeri, Siri Tahtinen, Yuchen Fan, Chun-Wan Yen, Maheswara Reddy Emani (2025). Predictive in vitro profiling of LNP-induced innate immune response using an iPSC-derived monocyte model. bioRxiv.
DOI
Tawaun A. Lucas, Gloriia Novikova, Sadhna Rao, Yuanyuan Wang, Benjamin I. Laufer, Shristi Pandey, Michelle G. Webb, Nikolas Jorstad, Brad A. Friedman, Jesse E. Hanson, Joshua S. Kaminker (2025). Integrated Cross-Disease Atlas of Human And Mouse Astrocytes Reveals Heterogeneity and Conservation of Astrocyte Subtypes in Neurodegeneration. bioRxiv.
DOI
Sara L. Dominguez, Benjamin I. Laufer, Arundhati Sengupta Ghosh, Qingling Li, Gaia Ruggeri, Maheswara Reddy Emani, Lilian Phu, Brad A. Friedman, Wendy Sandoval, Christopher M. Rose, Hai Ngu, Oded Foreman, Mike Reichelt, Yves Juste, Guita Lalehzadeh, Dennis Hansen, Helle Nymark, Denia Mellal, Helene Gylling, Łukasz J. Kiełpiʼnski, Ben Chih, Baris Bingol, Casper C. Hoogenraad, William J. Meilandt, Amy Easton (2023). TMEM106B reduction does not rescue GRN deficiency in iPSC-derived human microglia and mouse models. iScience.
DOI
Amy E. Byrnes, Sara L. Dominguez, Chun-Wan Yen, Benjamin I. Laufer, Oded Foreman, Mike Reichelt, Han Lin, Meredith Sagolla, Kathy Hötzel, Hai Ngu, Christoffer Soendergaard, Alberto Estevez, Hsiu-Chao Lin, Alexandre Goyon, Juan Bian, Jessica Lin, Flora I. Hinz, Brad A. Friedman, Amy Easton, Casper C. Hoogenraad (2023). Lipid nanoparticle delivery limits antisense oligonucleotide activity and cellular distribution in the brain after intracerebroventricular injection. Molecular Therapy — Nucleic Acids.
DOI
See all publications