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TMEM106B reduction does not rescue GRN deficiency in iPSC-derived human microglia and mouse models
Heterozygous mutations in the granulin (GRN) gene are a leading cause of frontotemporal lobar degeneration with TDP-43 aggregates …
Lipid nanoparticle delivery limits antisense oligonucleotide activity and cellular distribution in the brain after intracerebroventricular injection
Antisense oligonucleotide (ASO) therapeutics are being investigated for a broad range of neurological diseases. While ASOs have been …
Multi-omic brain and behavioral correlates of cell-free fetal DNA methylation in macaque maternal obesity models
Maternal obesity during pregnancy is associated with neurodevelopmental disorder (NDD) risk. We utilized integrative multi-omics to …
Disease-associated oligodendrocyte responses across neurodegenerative diseases
Oligodendrocyte dysfunction has been implicated in the pathogenesis of neurodegenerative diseases, so understanding oligodendrocyte …
Placental methylome reveals a 22q13.33 brain regulatory gene locus associated with autism
BACKGROUND: Autism spectrum disorder (ASD) involves complex genetics interacting with the perinatal environment, complicating the …