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Stable DNMT3L overexpression in SH-SY5Y neurons recreates a facet of the genome-wide Down syndrome DNA methylation signature
Background: Down syndrome (DS) is characterized by a genome-wide profile of differential DNA methylation that is skewed towards …
Benjamin I. Laufer, J. Antonio Gomez, Julia M. Jianu, Janine M. LaSalle
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Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked genes
Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex heritability and higher prevalence in males. …
Charles E. Mordaunt, Julia M. Jianu, Benjamin I. Laufer, Yihui Zhu, Hyeyeon Hwang, Keith W. Dunaway, Kelly M. Bakulski, Jason I. Feinberg, Heather E. Volk, Kristen Lyall, Lisa A. Croen, Craig J. Newschaffer, Sally Ozonoff, Irva Hertz-Picciotto, M. Daniele Fallin, Rebecca J. Schmidt, Janine M. LaSalle
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Low-pass whole genome bisulfite sequencing of neonatal dried blood spots identifies a role for RUNX1 in down syndrome DNA methylation profiles
Neonatal dried blood spots (NDBS) are a widely banked sample source that enables retrospective investigation into early life molecular …
Benjamin I. Laufer, Hyeyeon Hwang, Julia M. Jianu, Charles E. Mordaunt, Ian F. Korf, Irva Hertz-Picciotto, Janine M. LaSalle
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Whole genome bisulfite sequencing of Down syndrome brain reveals regional DNA hypermethylation and novel disorder insights
Down Syndrome (DS) is the most common genetic cause of intellectual disability, in which an extra copy of human chromosome 21 (HSA21) …
Benjamin I. Laufer, Hyeyeon Hwang, Annie Vogel Ciernia, Charles E. Mordaunt, Janine M. LaSalle
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Epigenomic Convergence of Neural-Immune Risk Factors in Neurodevelopmental Disorder Cortex
Neurodevelopmental disorders (NDDs) affect 7-14% of all children in developed countries and are one of the leading causes of lifelong …
Annie Vogel Ciernia, Benjamin I. Laufer, Hyeyeon Hwang, Keith W. Dunaway, Charles E. Mordaunt, Rochelle L. Coulson, Dag H. Yasui, Janine M. LaSalle
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Imprinting effects of UBE3A loss on synaptic gene networks and Wnt signaling pathways
Ubiquitin E3 ligase 3A (UBE3A) encodes an E3 ubiquitin ligase whose loss from the maternal allele causes the neurodevelopmental …
S. Jesse Lopez, Benjamin I. Laufer, Ulrika Beitnere, Elizabeth L. Berg, Jill L. Silverman, Henriette O'geen, David J. Segal, Janine M. LaSalle
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Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex
Rhythmic oscillations of physiological processes depend on integrating the circadian clock and diurnal environment. DNA methylation is …
Rochelle L. Coulson, Dag H. Yasui, Keith W. Dunaway, Benjamin I. Laufer, Annie Vogel Ciernia, Yihui Zhu, Charles E. Mordaunt, Theresa S. Totah, Janine M. LaSalle
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Experience-dependent neuroplasticity of the developing hypothalamus: integrative epigenomic approaches
Augmented maternal care during the first postnatal week promotes life-long stress resilience and improved memory compared with the …
Annie Vogel Ciernia, Benjamin I. Laufer, Keith W. Dunaway, Charles E. Mordaunt, Rochelle L. Coulson, Theresa S. Totah, Danielle S. Stolzenberg, Jaime C. Frahm, Akanksha Singh-Taylor, Tallie Z. Baram, Janine M. LaSalle, Dag H. Yasui
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Changes to histone modifications following prenatal alcohol exposure: An emerging picture
Epigenetic mechanisms are important for facilitating gene-environment interactions in many disease etiologies, including Fetal Alcohol …
Eric J. Chater-Diehl, Benjamin I. Laufer, Shiva M. Singh
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Long-term alterations to DNA methylation as a biomarker of prenatal alcohol exposure: From mouse models to human children with fetal alcohol spectrum disorders
Rodent models of Fetal Alcohol Spectrum Disorders (FASD) have revealed that prenatal alcohol exposure (PAE) results in differential DNA …
Benjamin I. Laufer, Eric J. Chater-Diehl, Joachim Kapalanga, Shiva M. Singh
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