"DNA Methylation"

Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked genes
Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex heritability and higher prevalence in males. …
Charles E. Mordaunt, Julia M. Jianu, Benjamin I. Laufer, Yihui Zhu, Hyeyeon Hwang, Keith W. Dunaway, Kelly M. Bakulski, Jason I. Feinberg, Heather E. Volk, Kristen Lyall, Lisa A. Croen, Craig J. Newschaffer, Sally Ozonoff, Irva Hertz-Picciotto, M. Daniele Fallin, Rebecca J. Schmidt, Janine M. LaSalle
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Whole genome bisulfite sequencing of Down syndrome brain reveals regional DNA hypermethylation and novel disorder insights
Down Syndrome (DS) is the most common genetic cause of intellectual disability, in which an extra copy of human chromosome 21 (HSA21) …
Benjamin I. Laufer, Hyeyeon Hwang, Annie Vogel Ciernia, Charles E. Mordaunt, Janine M. LaSalle
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Epigenomic Convergence of Neural-Immune Risk Factors in Neurodevelopmental Disorder Cortex
Neurodevelopmental disorders (NDDs) affect 7-14% of all children in developed countries and are one of the leading causes of lifelong …
Annie Vogel Ciernia, Benjamin I. Laufer, Hyeyeon Hwang, Keith W. Dunaway, Charles E. Mordaunt, Rochelle L. Coulson, Dag H. Yasui, Janine M. LaSalle
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Experience-dependent neuroplasticity of the developing hypothalamus: integrative epigenomic approaches
Augmented maternal care during the first postnatal week promotes life-long stress resilience and improved memory compared with the …
Annie Vogel Ciernia, Benjamin I. Laufer, Keith W. Dunaway, Charles E. Mordaunt, Rochelle L. Coulson, Theresa S. Totah, Danielle S. Stolzenberg, Jaime C. Frahm, Akanksha Singh-Taylor, Tallie Z. Baram, Janine M. LaSalle, Dag H. Yasui
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Long-term alterations to DNA methylation as a biomarker of prenatal alcohol exposure: From mouse models to human children with fetal alcohol spectrum disorders
Rodent models of Fetal Alcohol Spectrum Disorders (FASD) have revealed that prenatal alcohol exposure (PAE) results in differential DNA …
Benjamin I. Laufer, Eric J. Chater-Diehl, Joachim Kapalanga, Shiva M. Singh
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DNA methylation differences in monozygotic twin pairs discordant for schizophrenia identifies psychosis related genes and networks
Background: Despite their singular origin, monozygotic twin pairs often display discordance for complex disorders including …
Christina A. Castellani, Benjamin I. Laufer, Melkaye G. Melka, Eric J. Diehl, Richard L. O'Reilly, Shiva M. Singh
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DNA methylation in psychosis: Insights into etiology and treatment
Evidence for involvement of DNA methylation in psychosis forms the focus of this perspective. Of interest are results from two …
Christina A. Castellani, Melkaye G. Melka, Eric J. Diehl, Benjamin I. Laufer, Richard L. O'Reilly, Shiva M. Singh
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Long-term genomic and epigenomic dysregulation as a consequence of prenatal alcohol exposure: A model for fetal alcohol spectrum disorders
There is abundant evidence that prenatal alcohol exposure leads to a range of behavioral and cognitive impairments, categorized under …
Morgan L. Kleiber, Eric J. Diehl, Benjamin I. Laufer, Katarzyna Mantha, Aniruddho Chokroborty-Hoque, Bonnie Alberry, Shiva M. Singh
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The effects of olanzapine on genome-wide DNA methylation in the hippocampus and cerebellum
Background: The mechanism of action of olanzapine in treating schizophrenia is not clear. This research reports the effects of a …
Melkaye G. Melka, Benjamin I. Laufer, Patrick McDonald, Christina A. Castellani, Nagalingam Rajakumar, Richard O'Reilly, Shiva M. Singh
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Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice
Fetal alcohol spectrum disorders (FASDs) are characterized by life-long changes in gene expression, neurodevelopment and behavior. What …
Benjamin I. Laufer, Katarzyna Mantha, Morgan L. Kleiber, Eric J. Diehl, Sean M.F. Addison, Shiva M. Singh
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